TY - JOUR
T1 - The use of pharmacokinetic/pharmacodynamic principles to predict clinical outcome in paediatric acute otitis media
AU - Dagan, Ron
N1 - Funding Information:
This article is based on a paper presented at a GlaxoSmithKline-sponsored symposium entitled ‘Augmentin Heritage in Evolving Antibacterial Therapy’ held on 4th November 2006, London, UK. The assistance in developing the manuscript provided by Stella Deane was funded by GlaxoSmithKline.
Funding Information:
Funding: The data presented in this article are derived partially from a research grant provided by GlaxoSmithKline.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Double tympanocentesis studies of children with acute otitis media, carried out over an 11-year period, were used to confirm that pharmacokinetic (PK) and pharmacodynamic (PD) parameters can be used as predictors of the bacteriological and clinical efficacy of antimicrobial agents. Predicted susceptibilities of common respiratory pathogens, such as Streptococcus pneumoniae and Haemophilus influenzae, were compared with the bacteriological outcome of treatment in which the high-dose formulation of amoxicillin/clavulanate (90 mg/kg/day) given twice daily achieved the greatest bacteriological eradication rates for an oral agent. Further analysis of the data has indicated that failure to eradicate bacteria from the middle ear fluid is strongly correlated with clinical failure.
AB - Double tympanocentesis studies of children with acute otitis media, carried out over an 11-year period, were used to confirm that pharmacokinetic (PK) and pharmacodynamic (PD) parameters can be used as predictors of the bacteriological and clinical efficacy of antimicrobial agents. Predicted susceptibilities of common respiratory pathogens, such as Streptococcus pneumoniae and Haemophilus influenzae, were compared with the bacteriological outcome of treatment in which the high-dose formulation of amoxicillin/clavulanate (90 mg/kg/day) given twice daily achieved the greatest bacteriological eradication rates for an oral agent. Further analysis of the data has indicated that failure to eradicate bacteria from the middle ear fluid is strongly correlated with clinical failure.
KW - Amoxicillin/clavulanate
KW - Haemophilus influenzae
KW - Otitis media
KW - Pharmacodynamics
KW - Pharmacokinetics
KW - Streptococcus pneumoniae
UR - http://www.scopus.com/inward/record.url?scp=36048967667&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2007.07.039
DO - 10.1016/j.ijantimicag.2007.07.039
M3 - Article
C2 - 17980558
AN - SCOPUS:36048967667
VL - 30
SP - 127
EP - 130
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - SUPPL. 2
ER -
