The Use of Tamoxifen as a Potential Treatment for Bipolar Disorder

Noy Bagdadi, Abed N. Azab, Rachel Shvartsur

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Bipolar disorder (BD) is a chronic mental disease that substantially affects the patient’s quality of life and causes significant morbidity and mortality. Although there are a variety of available treatments, therapeutic intervention is not beneficial in many cases and recurrence rates remain high. Recent data suggested tamoxifen, a drug with a wide range of activities, as a potential treatment for reducing manic symptoms of BD. Tamoxifen’s therapeutic effect on bipolar mania has not been fully elucidated, but it is believed to biochemically operate on protein kinase C (PKC) inhibition. In this article, we review preclinical and clinical studies investigating the efficacy of tamoxifen as a potential treatment for bipolar manic patients.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
JournalPsychiatry and Clinical Psychopharmacology
Issue number3
StatePublished - Sep 2021


  • Antimanic treatment
  • bipolar disorder
  • mania
  • protein kinase C
  • tamoxifen

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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