The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

Naama Shoham; Natan T. Shaked; Dafna Benayahu; Amit Gefen

doi:10.1007/8415_2014_176

The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

Naama Shoham, Natan T. Shaked, Dafna Benayahu, Amit Gefen

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.

Original language	English
Title of host publication	Studies in Mechanobiology, Tissue Engineering and Biomaterials
Publisher	Springer
Pages	89-103
Number of pages	15
DOIs	https://doi.org/10.1007/8415_2014_176
State	Published - 1 Jan 2015
Externally published	Yes

Publication series

Name	Studies in Mechanobiology, Tissue Engineering and Biomaterials
Volume	16
ISSN (Print)	1868-2006
ISSN (Electronic)	1868-2014

Keywords

Adipose Tissue
Brown Adipose Tissue
Magnetic Resonance Elastography
Subcutaneous Adipose Tissue
White Adipose Tissue

ASJC Scopus subject areas

Biotechnology
Biophysics
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/8415_2014_176

Cite this

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title = "The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction",

abstract = "This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.",

keywords = "Adipose Tissue, Brown Adipose Tissue, Magnetic Resonance Elastography, Subcutaneous Adipose Tissue, White Adipose Tissue",

author = "Naama Shoham and Shaked, {Natan T.} and Dafna Benayahu and Amit Gefen",

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doi = "10.1007/8415_2014_176",

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The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction. / Shoham, Naama; Shaked, Natan T.; Benayahu, Dafna et al.
Studies in Mechanobiology, Tissue Engineering and Biomaterials. Springer, 2015. p. 89-103 (Studies in Mechanobiology, Tissue Engineering and Biomaterials; Vol. 16).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - The Vicious Cycle of Estrogen Consumption and Obesity

T2 - The Role of Mechanotransduction

AU - Shoham, Naama

AU - Shaked, Natan T.

AU - Benayahu, Dafna

AU - Gefen, Amit

PY - 2015/1/1

Y1 - 2015/1/1

N2 - This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.

AB - This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.

KW - Adipose Tissue

KW - Brown Adipose Tissue

KW - Magnetic Resonance Elastography

KW - Subcutaneous Adipose Tissue

KW - White Adipose Tissue

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M3 - Chapter

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T3 - Studies in Mechanobiology, Tissue Engineering and Biomaterials

SP - 89

EP - 103

BT - Studies in Mechanobiology, Tissue Engineering and Biomaterials

PB - Springer

ER -

The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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