The voltage-dependent anion channel characterization, modulation, and role in mitochondrial function in cell life and death

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166 Scopus citations

Abstract

Recently, it has been recognized that there is a metabolic coupling between the cytosol and mitochondria, where the outer mitochondrial membrane (OMM), the boundary between these compartments, has important functions. In this crosstalk, mitochondrial Ca2+ homeostasis and ATP production and supply play a major role. The primary transporter of ions and metabolites across the OMM is the voltage-dependent anion channel (VDAC). The interaction of VDAC with Ca2+, ATP glutamate, NADH, and different proteins was demonstrated, and these interactions may regulate OMM permeability. This review includes information on VDAC purification methods, characterization of its channel activity (selectivity, voltage-dependence, conductance), and the regulation of VDAC channel by ligands, such as Ca2+, glutamate and ATP and touches on many aspects of the physiological relevance of VDAC to Ca2+ homeostasis and mitochondria-mediated apoptosis.

Original languageEnglish
Pages (from-to)279-292
Number of pages14
JournalCell Biochemistry and Biophysics
Volume39
Issue number3
DOIs
StatePublished - 1 Dec 2003

Keywords

  • Ca homeostasis
  • Glutamate
  • Mitochondria
  • Porin
  • Single channel
  • VDAC

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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