The Weiss-Lapicque and the Lapicque-Blair strength-duration curves revisited

A. Rabinovitch, D. Braunstein, Y. Biton, M. Friedman, I. Aviram

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The Weiss-Lapicque and Lapicque-Blair relations connecting the strength of a stimulation pulse and its duration in order to attain a threshold are examined here in the case of the nonlinear FitzHugh-Nagumo (FHN) model system. The relation parameters can easilybederived and explained by analyzing the dynamical behavior at very short and very long pulse durations. This explanation should hold true for most nonlinear biological systems. It is seen that, for the FHN, both relations provide only approximations (albeit good ones) to the actual strength-duration curve.

Original languageEnglish
Article number015019
JournalBiomedical Physics and Engineering Express
Volume2
Issue number1
DOIs
StatePublished - 18 Feb 2016

Keywords

  • Blair
  • Chronaxie
  • FitzHugh-Nagumo system
  • Lapicque
  • Rheobase
  • Weiss strength-duration

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