The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte Transport

Seonghee Park, Jeong Hee Hong, Ehud Ohana, Shmuel Muallem

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Fluid and electrolyte homeostasis is a fundamental physiological function required for survival and is associated with a plethora of diseases when aberrant. Systemic fluid and electrolyte composition is regulated by the kidney, and all secretory epithelia generate biological fluids with defined electrolyte composition by vectorial transport of ions and the obligatory water. A major regulatory pathway that immerged in the last several years is regulation of ion transporters by the WNK/SPAK kinases and IRBIT/PP1 pathways. The IRBIT/PP1 pathway functions to reverse the effects of the WNK/SPAK kinases pathway, as was demonstrated for NBCe1-B and CFTR. Since many transporters involved in fluid and electrolyte homeostasis are affected by PP1 and/or calcineurin, it is possible that WNK/SPAK and IRBIT/PP1 form a common regulatory pathway to tune the activity of fluid and electrolyte transport in response to physiological demands.

Original languageEnglish
Pages (from-to)291-299
Number of pages9
Issue number5
StatePublished - 1 Oct 2012
Externally publishedYes

ASJC Scopus subject areas

  • Physiology


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