TY - JOUR
T1 - The yeast forkhead HCM1 controls life span independent of calorie restriction
AU - Maoz, Noam
AU - Gabay, Orshay
AU - Ben-Asher, Hiba Waldman
AU - Cohen, Haim Y.
N1 - Publisher Copyright:
© 2014 The Author.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Regulation of life span by members of the forkhead transcription factor family of proteins is one of the most highly investigated pathways in the field of aging. Nevertheless, despite the existence of forkhead family homologues in yeast, our knowledge of these proteins' role in yeast longevity is limited. Here, we show that yeast Hcm1p forkhead is the closest homologue of the worm PHA-4 forkhead, which regulates Caenorhabditis elegans life span. Overexpressing the yeast forkhead HCM1 or its deficiency resulted in a significant extension or reduction in yeast replicative life span, respectively. HCM1 regulates stress resistance, significantly increases the mRNA levels of several stress response genes including the catalase enzymes CTA1 and CTT1, and positively regulates life span independently of calorie restriction. Thus, HCM1 is a key regulator of life span, through a mechanism independent of calorie restriction.
AB - Regulation of life span by members of the forkhead transcription factor family of proteins is one of the most highly investigated pathways in the field of aging. Nevertheless, despite the existence of forkhead family homologues in yeast, our knowledge of these proteins' role in yeast longevity is limited. Here, we show that yeast Hcm1p forkhead is the closest homologue of the worm PHA-4 forkhead, which regulates Caenorhabditis elegans life span. Overexpressing the yeast forkhead HCM1 or its deficiency resulted in a significant extension or reduction in yeast replicative life span, respectively. HCM1 regulates stress resistance, significantly increases the mRNA levels of several stress response genes including the catalase enzymes CTA1 and CTT1, and positively regulates life span independently of calorie restriction. Thus, HCM1 is a key regulator of life span, through a mechanism independent of calorie restriction.
KW - Aging
KW - Forkhead
KW - HCM1
UR - http://www.scopus.com/inward/record.url?scp=84926652251&partnerID=8YFLogxK
U2 - 10.1093/gerona/glu059
DO - 10.1093/gerona/glu059
M3 - Article
C2 - 24835838
AN - SCOPUS:84926652251
SN - 1079-5006
VL - 70
SP - 444
EP - 453
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 4
ER -