As a preliminary investigation to a human study, the authors examined the pharmacokinetics of theophylline in pregnant and lactating rats. Three groups of female rats - pregnant, lactating, and virgin controls were injected IP with theophylline solution. Pregnant rats eliminated theophylline at a slower rate than both lactating rats and virgin controls, resulting in a longer half life (t1/2) and lower clearance. The approximate volume of distribution (aVd) and extrapolated peak concentration (Cp(O)) in the 3 groups were not different.
|Number of pages||3|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - 1 Dec 1986|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics (all)