Abstract
As a preliminary investigation to a human study, the authors examined the pharmacokinetics of theophylline in pregnant and lactating rats. Three groups of female rats - pregnant, lactating, and virgin controls were injected IP with theophylline solution. Pregnant rats eliminated theophylline at a slower rate than both lactating rats and virgin controls, resulting in a longer half life (t1/2) and lower clearance. The approximate volume of distribution (aVd) and extrapolated peak concentration (Cp(O)) in the 3 groups were not different.
| Original language | English |
|---|---|
| Pages (from-to) | 269-271 |
| Number of pages | 3 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 53 |
| Issue number | 2 |
| State | Published - 1 Dec 1986 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- General Pharmacology, Toxicology and Pharmaceutics