Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and145sm as a brachytherapy source

Joseph H. Goodman, Reinhard A. Gahbauer, Christos Kanellitsas, Nancy R. Clendenon, Brenda H. Laster, Ralph G. Fairchild

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine,192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting145Sm for192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.

Original languageEnglish
Pages (from-to)531-534
Number of pages4
JournalStereotactic and Functional Neurosurgery
Volume54
Issue number1-8
DOIs
StatePublished - 1 Jan 1990
Externally publishedYes

Keywords

  • Brain tumor
  • Radiation enhancement
  • Radiotherapy
  • Stereotactic surgery

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