Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and145sm as a brachytherapy source

Joseph H. Goodman; Reinhard A. Gahbauer; Christos Kanellitsas; Nancy R. Clendenon; Brenda H. Laster; Ralph G. Fairchild

doi:10.1159/000100268

Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and¹⁴⁵sm as a brachytherapy source

Joseph H. Goodman
, Reinhard A. Gahbauer
, Christos Kanellitsas
, Nancy R. Clendenon
, Brenda H. Laster
, Ralph G. Fairchild

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine,¹⁹²Ir as a brachytherapy source, and external radiation have produced promising results. Substituting¹⁴⁵Sm for¹⁹²Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.

Original language	English
Pages (from-to)	531-534
Number of pages	4
Journal	Stereotactic and Functional Neurosurgery
Volume	54
Issue number	1-8
DOIs	https://doi.org/10.1159/000100268
State	Published - 1 Jan 1990
Externally published	Yes

Keywords

Brain tumor
Radiation enhancement
Radiotherapy
Stereotactic surgery

ASJC Scopus subject areas

Surgery
Clinical Neurology

Access to Document

10.1159/000100268

Cite this

Goodman, J. H., Gahbauer, R. A., Kanellitsas, C., Clendenon, N. R., Laster, B. H., & Fairchild, R. G. (1990). Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and¹⁴⁵sm as a brachytherapy source. Stereotactic and Functional Neurosurgery, 54(1-8), 531-534. https://doi.org/10.1159/000100268

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title = "Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and145sm as a brachytherapy source",

abstract = "A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine,192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting145Sm for192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.",

keywords = "Brain tumor, Radiation enhancement, Radiotherapy, Stereotactic surgery",

author = "Goodman, \{Joseph H.\} and Gahbauer, \{Reinhard A.\} and Christos Kanellitsas and Clendenon, \{Nancy R.\} and Laster, \{Brenda H.\} and Fairchild, \{Ralph G.\}",

year = "1990",

month = jan,

day = "1",

doi = "10.1159/000100268",

language = "English",

volume = "54",

pages = "531--534",

journal = "Stereotactic and Functional Neurosurgery",

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Goodman, JH, Gahbauer, RA, Kanellitsas, C, Clendenon, NR, Laster, BH & Fairchild, RG 1990, 'Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and¹⁴⁵sm as a brachytherapy source', Stereotactic and Functional Neurosurgery, vol. 54, no. 1-8, pp. 531-534. https://doi.org/10.1159/000100268

Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and¹⁴⁵sm as a brachytherapy source. / Goodman, Joseph H.; Gahbauer, Reinhard A.; Kanellitsas, Christos et al.
In: Stereotactic and Functional Neurosurgery, Vol. 54, No. 1-8, 01.01.1990, p. 531-534.

Research output: Contribution to journal › Article › peer-review

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AU - Clendenon, Nancy R.

AU - Laster, Brenda H.

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AB - A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine,192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting145Sm for192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.

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KW - Radiation enhancement

KW - Radiotherapy

KW - Stereotactic surgery

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