@article{cc6a1fca707d471db7d745b838b1bc39,
title = "Theoretical Investigation of Using a Yellow (577nm) Laser for Diabetic Retinopathy",
abstract = "We present a theoretical analysis of laser coagulation for diabetic retinopathy (DR) eye surgery procedures. Using a Monte-Carlo multi-layer (MCML) simulation and a finite element model of the human eye, we derive the optimal surgery conditions and address the long standing debate regarding the best laser wavelength to be used. The differences between yellow (577nm) and green (532nm) lasers, which are the commonly used wavelengths for this procedure, have been studied previously, mostly via empirical studies. Here, to the best of our knowledge, we introduce for the first time a quantitative theoretical analysis to determine the best laser wavelength. Using our analysis, we determine optimal laser operation conditions for treating DR with minimal damage to the surrounding tissue. We show that under these conditions, the yellow laser is significantly favorable.",
author = "Kobi Aflalo and Moshe Ben-David and Adrian Stern and Irit Juwiler",
note = "Funding Information: The behavioral abnormalities constituting the alcohol withdrawal reaction have been considered to reflect the release of a latent state of increased neural excitability developed as a result of continuous exposure to alcohol (Kalant et al., 1971). There exists at present little direct evidence regarding the involvement of specific brain regions in the development of the neural hyperexcitability. One technique that has not been effectively utilized is the recording of electrographic (EEG) activity during the withdrawal reaction. Wikler et al. (1956) in studies of the alcohol withdrawal syndrome in man characterized the EEG abnormalities as mild in comparison to those of barbiturate withdrawal, thereby implicating subcortical regions in the genesis of the withdrawal reaction. In preliminary studies in alcohol-dependent mice {Walker and Zornetzer 1974) and rats (Hunter et al. 1973) we observed a progressive development of epileptiform abnormalities from chronically implanted depth electrodes in a variety of forebrain regions. The widespread nature of forebrain involvement in abnormal patterns of EEG activity suggested two alter- I This work was supported by the Veterans Adminis-tration and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Grant No. AA-00200 to D.W.W.B.E.H. was supported by NIAAA Predoc-total Fellowship No. AA-05022 and J.N.R. was sup-ported by NIAAA Predoctoral Fellowship No. AA-05029. Publisher Copyright: {\textcopyright} 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement",
year = "2020",
month = nov,
day = "15",
doi = "10.1364/OSAC.399120",
language = "English",
volume = "3",
pages = "3253--3266",
journal = "OSA Continuum",
issn = "2578-7519",
publisher = "OSA - The Optical Society",
number = "11",
}
