@article{25f59019ba7a451bbb710a9647b748bc,
title = "Therapeutic effects of S-35-thiouracil in balb/c mice carrying harding-passey melanoma",
abstract = "Thiouracil (TU) selectively binds to the pigment melanin during melanogenesis and is rapidly cleared from normal tissues. This compound shows little affinity for pre-formed melanin. BALB/c mice, carrying the subcutaneously transplanted Harding-Passey melanoma, were given i.p. injections of 35S-labeled thiouracil in a range of doses and administration schedules. Injected doses ranged from 1.3 to 10 mCi per mouse with resultant tumor dose rates of 10 to 30 cGy/hr, respectively. At the lower dose rates, growth delay of ∼1 to 2 weeks was observed in all tumors. At the highest doses used, complete tumor regression (no regrowth) was observed in some cases, with extended growth delays of ∼6 weeks in the rest. These results illustrate the possible utility of radiolabeled thiouracil as a systemically administered brachytherapy agent for melanoma.",
keywords = "Brachytherapy, Harding-Passey melanoma, Thiouracil",
author = "Fairchild, {R. G.} and Coderre, {J. A.} and S. Packer and D. Greenberg and Laster, {B. H.}",
note = "Funding Information: This work was supported by Grant number CA 33725 from the National Institutes of Health and under Contract number DE-AC02-76CHOOO16w ith the U.S. Department of Energy. Accordingly the U.S. Government retains a nonexclusive, roy- and of mode of administration. The distribution of TU labeled with each of the above tags was evaluated, with similar results (4, 10). In the latter work, uptake in tumor (Harding-Passey melanotic melanoma carried in BALB/ c mice) and various normal tissues was evaluated in terms of pg TU per gram of tissue following graded doses of TU. It was found that even with high doses of TU (125 pg TU per gram body weight), uptake in tumor was high (-10% injected dose per gram tumor) and that tumor: normal tissue ratios varied from - 50: 1 in metabolizing organs (lung, liver) to - 300: 1 in muscle and brain, within 1 day after administration. In particular, it was confirmed that little or no affinity exists between TU and preformed melanin (tumor:whole eye ratio = 80: 1, in Chinese hamsters). Studies with 5-iodo-thiouracil in our lab and by others have shown that the iodinated form is taken up in melanoma about as well as TU itself, thus permitting the possibility of the diagnosis of metastatic melanoma (4, 15, 18, 24). Clinical evaluation of this procedure is under way.",
year = "1989",
month = jan,
day = "1",
doi = "10.1016/0360-3016(89)90448-3",
language = "English",
volume = "17",
pages = "337--343",
journal = "International journal of radiation oncology, biology, physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "2",
}
