Therapy of neurodegenerative diseases using neurotrophic factors: Cell biological perspective

Claude Brodski, Daniela M. Vogt Weisenhorn, Georg Dechant

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Neurotrophic growth factors are a structurally diverse group of endogenous proteins, which profoundly regulate survival and multiple other cellular functions of healthy and diseased neurons. Their physiological targets include all neuronal cell types affected by neurodegenerative diseases. Initial clinical trials, which were based on strong and convincing neuroprotective effects in animal models of neurodegenerative diseases, have failed so far. In this review, we adopt a cell biological perspective to outline both the potential and problems of the therapeutic use of trophic factors in the nervous system. Emphasis is given to the functional interplay of neurotrophic factors in the regulation of cell death, as well as to the effects these proteins exert on neuronal morphology and synaptic transmission.

Original languageEnglish
Pages (from-to)417-426
Number of pages10
JournalExpert Review of Neurotherapeutics
Volume2
Issue number3
DOIs
StatePublished - 24 Jun 2002
Externally publishedYes

Keywords

  • ALS
  • Alzheimer's disease
  • BDNF
  • CNTF
  • GDNF
  • NGF
  • Neurodegeneration
  • Neurotrophin
  • Parkinson's disease
  • Ret
  • Trk

ASJC Scopus subject areas

  • Neuroscience (all)
  • Clinical Neurology
  • Pharmacology (medical)

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