Chlorotris[diphenyl(m-sulphonatophenyl)phosphine]rhodium(I) acts as a homogeneous catalyst in the thermal and photoinduced regeneration of natural nicotinamide adenine dinucleotide cofactors, NAD(P)+, and of a model compound 1-benzylnicotinamide. The thermal regeneration system uses formate as the hydride donor. The kinetics of the system has been studied and shows enzyme-like characteristics. The photoinduced regeneration system with Ru(bpy)32+ as the photosensitizer and ascorbate as the electron donor proceeds through formation of a rhodium-hydrido active species. The photoregenerated cofactors are subsequently coupled to the enzymatic reduction of acetaldehyde to ethanol, or to the model enzymatic reduction of benzil to benzoin.
|Number of pages||6|
|Journal||Journal of the Chemical Society. Perkin Transactions 2|
|State||Published - 1 Jan 1990|