Abstract
With a combination of solid phase and solution phase peptide synthesis, we designed and synthesized a series of wedge-shaped triblock peptide-polymer-C16 (palmitic acid) conjugate amphiphiles. With a variety of techniques, we investigated their hierarchical structures and phase behavior. The amphiphiles were thermoresponsive and showed a morphology change from small
micelles to large aggregates as hypothesized. The hydrophilic shell and strong tendency for micelle formation limited the thermoresponsive assembly, leading to slow turbidity change in the LCST transition. The secondary structure was twisted from conventional β-sheet, and the thermoresponsive trend observed in typical ELP systems was not observed, either. Variable temperature NMR showed evidence for coherent dehydration of the PEG and ELP segments, probably due to the relatively short blocks. Utilizing the micelles with hydrophobic cavity, we
encapsulated hydrophobic drugs with potential applications in hyperthermia.
micelles to large aggregates as hypothesized. The hydrophilic shell and strong tendency for micelle formation limited the thermoresponsive assembly, leading to slow turbidity change in the LCST transition. The secondary structure was twisted from conventional β-sheet, and the thermoresponsive trend observed in typical ELP systems was not observed, either. Variable temperature NMR showed evidence for coherent dehydration of the PEG and ELP segments, probably due to the relatively short blocks. Utilizing the micelles with hydrophobic cavity, we
encapsulated hydrophobic drugs with potential applications in hyperthermia.
| Original language | English GB |
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| Title of host publication | Elastin-Like Peptide Dendrimers |
| Subtitle of host publication | Design, Synthesis, and Applications |
| Publisher | Virginia Polytechnic Institute |
| Number of pages | 1 |
| State | Published - 2019 |
Publication series
| Name | Elastin-Like Peptide Dendrimers: Design, Synthesis, and Applications |
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