Thiamine supplementation increases serum thiamine and reduces pyruvate and lactate levels in burn patients

Sian Falder, Robyn Silla, Michael Phillips, Suzanne Rea, Reuven Gurfinkel, Esther Baur, Anthony Bartley, Fiona M. Wood, Mark W. Fear

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The importance of vitamins for optimal metabolism is well established. However, currently little is known about the optimal vitamin levels required for burn patients. As a consequence, current practice both for macronutrient supplementation and vitamin supplementation varies widely between burn units. A better understanding of the effects of vitamins on metabolism may lead to better nutrition and subsequently improved outcomes for burn patients. Thiamine is an important co-factor required for multiple enzymes involved in carbohydrate metabolism. We have examined the levels of thiamine (B1) in burn patients as well as the effects of thiamine supplementation on the levels of serum thiamine, pyruvate and lactate. Twenty patients had blood samples taken on the day of admission, then on days 1, 3, and 7 post-admission and weekly thereafter until discharge. Of these, nine received enteral feeding. Six patients received thiamine supplementation. Serum thiamine, pyruvate and lactate levels were measured at each time point. Serum thiamine levels increased significantly with thiamine supplementation (p < 0.001). Serum thiamine levels also increased with time of supplementation (p < 0.001). Serum thiamine level was closely associated with pyruvate and lactate levels, with a decrease in both pyruvate and lactate associated with increased serum thiamine. Lastly, pyruvate and lactate levels appear closely associated in a linear relationship. This study suggests thiamine supplementation increases serum thiamine and that this increase is associated with a decrease in pyruvate and lactate levels. Further study of changes in metabolic flux associated with thiamine supplementation and a randomised control trial of thiamine supplementation are required to establish whether thiamine supplementation is beneficial to burn patients' metabolism and recovery.

Original languageEnglish
Pages (from-to)261-269
Number of pages9
Issue number2
StatePublished - 1 Mar 2010
Externally publishedYes


  • Burn injury
  • Metabolism
  • Pyruvate
  • Thiamine supplementation

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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