Third stage of labor placental complications and placenta-associated syndromes

Reut Rotem, Alisa Lipski, Adi Y. Weintraub, Yael Baumfeld, David Yohay, Fernanda Press, Gali Pariente

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To evaluate the association between third stage placental complications and placental insufficiency associated disorders, also known as, placenta associated syndromes. Study design: A population-based retrospective cohort study comparing placental-related perinatal outcomes of parturient with (study group) and without third stage placental complications, defined as a composite of retained placenta, adherent placenta, placenta accrete, need for manual removal of the placenta, postpartum curettage and revision of the uterine cavity. A univariate analysis was followed by a multivariable logistic regression model. Results: During the study period, 263,023 deliveries met inclusion criteria, of which, 10,281 (3.9%) experienced placental complications during the third stage of labor. Parturient in the study group had significantly higher rates of placental insufficiency associated disorders which included among others: hypertensive disorders of pregnancy (6.5 versus 5.6%, p <.001), stillbirth (1.9 versus 0.7%, p <.001) and preterm delivery (9.9 versus 7.7%, p <.001). Using a multivariable regression model, while controlling for confounders such as maternal age and induction of labor, third stage placental complications were independently associated with placental insufficiency associated disorders. Conclusion: Our findings suggest that placental associated adverse pregnancy outcomes and third stage placental complications may represent different manifestations of a common pathological or inadequate placentation process.

Original languageEnglish
Pages (from-to)3350-3354
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number20
StatePublished - 1 Jan 2021
Externally publishedYes


  • Hypertension in pregnancy
  • placenta
  • preterm birth
  • stillbirth
  • third stage of labor placental complication

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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