Thrombin-induced calcium-independent degranulation of human neutrophils

Danny Baranes, Jacob Matzner, Ehud Razin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Thrombin, a highly specific coagulation factor, can rapidly trigger lysozyme release from human neutrophils without concomitant activation of the 5-lipoxygenase pathway. This activation was not dependent on the presence of extracellular calcium. Since thrombin also induces the release of hemostatic and inflammatory metabolites from platelets and mast cells, it is proposed that it plays a significant role in amplification of the inflammatory response.

Original languageEnglish
Pages (from-to)455-461
Number of pages7
Issue number4
StatePublished - 1 Dec 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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