Thrombocytopenia in children infected with human immunodeficiency virus: Long-term follow-up and therapeutic considerations

Mona Rigaud, Eugene Leibovitz, Aditya Kaul, Henry Pollack, Robert Lawrence, David Dijohn, Keith Krasinski, William Borkowsky

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24 Scopus citations

Abstract

Among 180 children infected with human immunodeficiency virus (HIV–1), 14 (8%) developed thrombocytopenia during the course of the disease and have been followed for an average period of 18.8 months. Eight of 14 patients had clinical signs of bleeding. Increased levels of anti–platelet IgG antibodies were detected in 86% of patients tested and did not correlate with severity of disease. Eight patients were treated initially with intravenous immunoglobulins (IVIG) and responded with a transient increase in the platelet count of at least 30 x 109/L. Sustained remission could not be achieved in the patients treated with IVIG alone. Corticosteroids were used in 6 patients who became refractory to IVIG and resulted in sustained remission in only one patient. Spontaneous remission of thrombocytopenia occurred in one patient. Ten patients were treated with zidovudine (ZVD) for a period of 3-20 months. Sustained improvement in the platelet counts occurred in only three of the children treated with ZVD. Key Words: Thrombocytopenia-HIV–1 infection–Zidovudine therapy.

Original languageEnglish
Pages (from-to)441-449
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
Issue number5
StatePublished - 1 Jan 1992
Externally publishedYes

Keywords

  • HIV-1 infection
  • Thrombocytopenia
  • Zidovudine therapy

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