Thromboembolic events in patients with severe pandemic influenza A/H1N1

Lone Sølling Avnon, Daniela Munteanu, Alexander Smoliakov, Alan Jotkowitz, Leonid Barski

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Background The 2009 pandemic influenza A/H1N1 developed as a novel swine influenza which caused more diseases among younger age groups than in the elderly. Severe hypoxemic respiratory failure from A/H1N1 pneumonia resulted in an increased need for ICU beds. Several risk groups were identified that were at a higher risk for adverse outcomes. Pregnant women were a particularly vulnerable group of patients The CDC reported on the first ten patients with severe illness and acute hypoxemic respiratory failure associated with A/H1N1 infection, none of whom were pregnant, but they noticed that half of the patients had a pulmonary embolism. Methods During a four-month period from September to December 2009, 252 patients were admitted to our hospital with confirmed pandemic influenza H1N1 by real-time reverse transcriptase-polymerase chain reaction test (rRT-PCR). We cared for twenty patients (7.9%) admitted to MICU with severe A/H1N1. Results on Thrombotic events were identified in five (25%) of our critically ill patients. Conclusions We recommend that patients with severe influenza A/H1N1 pneumonitis and respiratory failure be administered DVT prophylaxis in particular if there are additional risk factors for TVE. Further prospective studies on the relationship of influenza A/H1N1 and VTE are needed.

Original languageEnglish
Pages (from-to)596-598
Number of pages3
JournalEuropean Journal of Internal Medicine
Issue number8
StatePublished - 1 Oct 2015
Externally publishedYes


  • Influenza A/H1N1
  • Mortality
  • Pregnancy
  • Thromboembolism

ASJC Scopus subject areas

  • Internal Medicine


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