Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure

Yaron Bar-Dayan, Moshe Aronson, Myra Small

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Age-related decline of the thymus in ICR female mice was studied following long-term (three month) weekly exposure to hydrocortisone acetate. When examined one week after cortisone injections, the well-known thymic atrophy was observed. Five weeks after 12 hydrocortisone injections, the cortical volume fraction (Vc), cortical/medullary ratio (C/M), the number of thymocytes and CD4/CD8 profiles were in the range that characterizes younger mice, compared with PBS-injected mice, uninjected controls, or mice given a single hydrocortisone injection 5 weeks earlier. It seems as if thymic involution with age was suspended during the period of glucocorticoid exposure.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalCell and Tissue Research
Volume290
Issue number3
DOIs
StatePublished - 19 Dec 1997
Externally publishedYes

Keywords

  • Anino
  • Morphometry
  • Prolonged hydrocortisone exposure
  • Thymic involution

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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