Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure

Yaron Bar-Dayan; Moshe Aronson; Myra Small

doi:10.1007/s004410050966

Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure

Yaron Bar-Dayan, Moshe Aronson, Myra Small

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Age-related decline of the thymus in ICR female mice was studied following long-term (three month) weekly exposure to hydrocortisone acetate. When examined one week after cortisone injections, the well-known thymic atrophy was observed. Five weeks after 12 hydrocortisone injections, the cortical volume fraction (Vc), cortical/medullary ratio (C/M), the number of thymocytes and CD4/CD8 profiles were in the range that characterizes younger mice, compared with PBS-injected mice, uninjected controls, or mice given a single hydrocortisone injection 5 weeks earlier. It seems as if thymic involution with age was suspended during the period of glucocorticoid exposure.

Original language	English
Pages (from-to)	609-613
Number of pages	5
Journal	Cell and Tissue Research
Volume	290
Issue number	3
DOIs	https://doi.org/10.1007/s004410050966
State	Published - 19 Dec 1997
Externally published	Yes

Keywords

Anino
Morphometry
Prolonged hydrocortisone exposure
Thymic involution

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

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10.1007/s004410050966

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title = "Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure",

abstract = "Age-related decline of the thymus in ICR female mice was studied following long-term (three month) weekly exposure to hydrocortisone acetate. When examined one week after cortisone injections, the well-known thymic atrophy was observed. Five weeks after 12 hydrocortisone injections, the cortical volume fraction (Vc), cortical/medullary ratio (C/M), the number of thymocytes and CD4/CD8 profiles were in the range that characterizes younger mice, compared with PBS-injected mice, uninjected controls, or mice given a single hydrocortisone injection 5 weeks earlier. It seems as if thymic involution with age was suspended during the period of glucocorticoid exposure.",

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author = "Yaron Bar-Dayan and Moshe Aronson and Myra Small",

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T1 - Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure

AU - Bar-Dayan, Yaron

AU - Aronson, Moshe

AU - Small, Myra

PY - 1997/12/19

Y1 - 1997/12/19

N2 - Age-related decline of the thymus in ICR female mice was studied following long-term (three month) weekly exposure to hydrocortisone acetate. When examined one week after cortisone injections, the well-known thymic atrophy was observed. Five weeks after 12 hydrocortisone injections, the cortical volume fraction (Vc), cortical/medullary ratio (C/M), the number of thymocytes and CD4/CD8 profiles were in the range that characterizes younger mice, compared with PBS-injected mice, uninjected controls, or mice given a single hydrocortisone injection 5 weeks earlier. It seems as if thymic involution with age was suspended during the period of glucocorticoid exposure.

AB - Age-related decline of the thymus in ICR female mice was studied following long-term (three month) weekly exposure to hydrocortisone acetate. When examined one week after cortisone injections, the well-known thymic atrophy was observed. Five weeks after 12 hydrocortisone injections, the cortical volume fraction (Vc), cortical/medullary ratio (C/M), the number of thymocytes and CD4/CD8 profiles were in the range that characterizes younger mice, compared with PBS-injected mice, uninjected controls, or mice given a single hydrocortisone injection 5 weeks earlier. It seems as if thymic involution with age was suspended during the period of glucocorticoid exposure.

KW - Anino

KW - Morphometry

KW - Prolonged hydrocortisone exposure

KW - Thymic involution

UR - https://www.scopus.com/pages/publications/0030831357

U2 - 10.1007/s004410050966

DO - 10.1007/s004410050966

M3 - Article

AN - SCOPUS:0030831357

SN - 0302-766X

VL - 290

SP - 609

EP - 613

JO - Cell and Tissue Research

JF - Cell and Tissue Research

IS - 3

ER -

Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure

Abstract

Keywords

ASJC Scopus subject areas

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