Thymocyte progenitors and T cell development in aging

Shiguang Yu, Loya Abel, Amiela Globerson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Dysfunction of T lymphocytes in aging has been causally related to a gradual loss of the thymic microenvironmental function. However, in view of the fact that T cells are generated from bone marrow-derived stem cells that settle in the thymus, we have investigated the possibility that aging effects on the bone marrow have an impact on T cell development. Our approach was based on seeding of bone marrow cells, from young and old mice, onto lymphoid-depleted fetal thymus explants, and examining the patterns of T lymphocyte development under organ culture conditions. The results indicate multifactorial effects of aging, on pre-thymic and intra-thymic developmental processes, as well as on feedback regulation by mature T cells.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
JournalMechanisms of Ageing and Development
Volume94
Issue number1-3
DOIs
StatePublished - 1 Mar 1997
Externally publishedYes

Keywords

  • Cell cycle
  • Hematopoiesis
  • Pgp-1
  • Stem cells
  • Thymocytes

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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