Thymus-derived lymphocytes: Humoral and cellular reactions distinguished by hydrocortisone

Shraga Segal; Irun R. Cohen; Michael Feldman

doi:10.1126/science.175.4026.1126

Thymus-derived lymphocytes: Humoral and cellular reactions distinguished by hydrocortisone

Shraga Segal, Irun R. Cohen, Michael Feldman

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74 Scopus citations

Abstract

Lymphocytes derived from the thymus (T cells) take part in the induction of humoral antibody and also effect cell-mediated graft-versus-host reactions. Preliminary treatment of mice with hydrocortisone caused an inhibition of T-cell function in humoral immunity, while enhancing the graft-versus-host reactivity of the same population of spleen cells. This suggests that different types of T cells participate in cellular and humoral immune reactions.

Original language	English
Pages (from-to)	1126-1128
Number of pages	3
Journal	Science
Volume	175
Issue number	4026
DOIs	https://doi.org/10.1126/science.175.4026.1126
State	Published - 1 Jan 1972
Externally published	Yes

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title = "Thymus-derived lymphocytes: Humoral and cellular reactions distinguished by hydrocortisone",

abstract = "Lymphocytes derived from the thymus (T cells) take part in the induction of humoral antibody and also effect cell-mediated graft-versus-host reactions. Preliminary treatment of mice with hydrocortisone caused an inhibition of T-cell function in humoral immunity, while enhancing the graft-versus-host reactivity of the same population of spleen cells. This suggests that different types of T cells participate in cellular and humoral immune reactions.",

author = "Shraga Segal and Cohen, {Irun R.} and Michael Feldman",

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AU - Cohen, Irun R.

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AB - Lymphocytes derived from the thymus (T cells) take part in the induction of humoral antibody and also effect cell-mediated graft-versus-host reactions. Preliminary treatment of mice with hydrocortisone caused an inhibition of T-cell function in humoral immunity, while enhancing the graft-versus-host reactivity of the same population of spleen cells. This suggests that different types of T cells participate in cellular and humoral immune reactions.

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Thymus-derived lymphocytes: Humoral and cellular reactions distinguished by hydrocortisone

Abstract

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