Thyroid function tests in newborns of mothers with hypothyroidism

Alon Haim, Tamar Wainstock, Shlomo Almashanu, Neta Loewenthal, Eyal Sheiner, Eli Hershkovitz, Daniela Landau

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Performing thyroid function tests (TFT) at 2 weeks of age in neonates of mothers with hypothyroidism, despite having a newborn screening program, is a debated approach. We examined whether there is an additional clinical benefit in TFT at 2 weeks of age in neonates born to mothers with hypothyroidism, in addition to the neonatal screening program. We performed a retrospective study which included all newborns of mothers with a diagnosis of hypothyroidism and gave birth in a single regional hospital between the years 2010 and 2016. Data were collected from a computerized medical record system of the hospital and the community clinics, and from Israel’s national newborn screening program. Main outcome measure was results of serum TFT in comparison to the results of the neonatal screening test. There were 1392 newborns eligible according to the study criteria. Of these, 1033 underwent a newborn screening test, and serum TFT at least 2 weeks after birth. Eight babies with congenital hypothyroidism were detected independently by both the newborn screening program and at the TFT performed at 2 weeks of age. Conclusions: No added clinical benefit was found in retesting newborns of hypothyroid mothers for thyroid function in addition to the newborn screening program.What is Known• Performing thyroid function test 2 weeks after birth is a common practice in newborn to a mother with hypothyroidism.• Neonatal screening program for thyroid function is also done in these newborns.What is New• No newborn was found to have a normal newborn screening test but abnormal serum thyroid function test.• No added clinical benefit was found in retesting newborns of hypothyroid mothers for thyroid function in addition to the newborn screening program.

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalEuropean Journal of Pediatrics
Volume180
Issue number2
DOIs
StatePublished - 1 Feb 2021

Keywords

  • Congenital hypothyroidism
  • Maternal hypothyroidism
  • Newborn screening program
  • Thyroid function test

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Thyroid function tests in newborns of mothers with hypothyroidism'. Together they form a unique fingerprint.

Cite this