Time-dependent sensitization: The odyssey of a scientific heresy from the laboratory to the door of the clinic

S. M. Antelman, J. Levine, S. Gershon

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses.

Original languageEnglish
Pages (from-to)350-356
Number of pages7
JournalMolecular Psychiatry
Volume5
Issue number4
DOIs
StatePublished - 1 Jan 2000
Externally publishedYes

Keywords

  • Antidepressants
  • Evolution
  • Immunological memory
  • Post-traumatic stress disorder
  • Pulsed therapy
  • Sensitization
  • Stress

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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