Time-kill determination of the bactericidal activity of telavancin and vancomycin against clinical methicillin-resistant Staphylococcus aureus isolates from cancer patients

Kenneth VI Rolston, Weiqun Wang, Lior Nesher, Jordan R. Smith, Michael J. Rybak, Randall A. Prince

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The bactericidal activity of vancomycin and telavancin was compared against 4 clinical methicillin-resistant Staphylococcus aureus isolates recently recovered from cancer patients, using minimum bactericidal concentration (MBC):MIC ratios and time-kill studies. All 4 isolates were susceptible to both agents based on individual MIC values. The 2 methodologies for assessing bactericidal activity produced variable results. Telavancin appeared to have somewhat better bactericidal activity than vancomycin based on narrower MBC:MIC ratios. However, based on the results of the time-kill studies, neither agent demonstrated reliable bactericidal activity (defined as a ≥3 log10 reduction of the starting inoculum at the end of 24 hours) against these organisms. These findings might be of some therapeutic importance in certain clinical settings and/or specific patient populations (such as febrile neutropenic patients) in whom potent bactericidal activity is either desired or preferred.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume87
Issue number4
DOIs
StatePublished - 1 Apr 2017
Externally publishedYes

Keywords

  • Bactericidal activity
  • Cancer patients
  • MRSA
  • Telavancin
  • Time-kill
  • Vancomycin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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