Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides

Gal Yosefi, Topaz Levi, Hanna Rapaport, Ronit Bitton

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Hierarchically ordered planar and spherical membranes (sacs) were constructed using amphiphilic and cationic β-sheet peptides that spontaneously assembled together with negatively charged alginate solution. The system was found to form either a fully developed membrane structure with three distinct regions including characteristic perpendicular fibers or a non-fully developed contact layer lacking these standing fibers, depending on the peptide age, membrane geometry and membrane incubation time. The morphological differences were found to strongly depend on fairly-long incubation time frames that influenced both the peptide's intrinsic alignment and the reaction-diffusion process taking place at the interface. A three-stage mechanism was suggested and key parameters affecting the development process were identified. Stability tests in biologically relevant buffers confirmed the suitability of these membranes for bio applications.

Original languageEnglish
Pages (from-to)10132-10142
Number of pages11
JournalSoft Matter
Issue number44
StatePublished - 28 Nov 2020

ASJC Scopus subject areas

  • Chemistry (all)
  • Condensed Matter Physics


Dive into the research topics of 'Time matters for macroscopic membranes formed by alginate and cationic β-sheet peptides'. Together they form a unique fingerprint.

Cite this