TY - JOUR
T1 - Tissue Acquisition During EBUS-TBNA
T2 - Comparison of Cell Blocks Obtained From a 19G Versus 21G Needle
AU - Pickering, Edward M.
AU - Holden, Van K.
AU - Heath, Jonathon E.
AU - Verceles, Avelino C.
AU - Kalchiem-Dekel, Or
AU - Sachdeva, Ashutosh
N1 - Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background:Previous studies have shown that needle gauge size has no significant impact on diagnostic yield during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Our objective was to determine whether cell blocks obtained via the new Flex 19G EBUS-TBNA needle would contain more cellular material based on cell area compared with those obtained from a 21G needle.Methods:A prospective analysis of patients undergoing EBUS-TBNA at our institutions was performed. Sampling of the same lesion(s) with both the Flex 19G and 21G needles was performed in an alternating manner. In total, 47 patients with suspected lung cancer or mediastinal/hilar lymphadenopathy were included with a total of 83 lesions biopsied. Cell block area was calculated using the Aperio ImageScope software.Results:Mean cell area in the Flex 19G group was 7.34±12.46 mm2 compared with 5.23±10.73 mm2 in the 21G group (P=0.02). In the malignant subgroup, the average cell area was 16.16±16.30 mm2 in the Flex 19G group versus 11.09±15.55 mm2 in the 21G group (P=0.02). No significant difference was noted in the mean cell area within the nonmalignant subgroup, 1.80±3.01 mm2 in the 19G group versus 1.56±1.79 mm2 in the 21G group (P=0.60).Conclusion:The cell area obtained via the 19G needle was significantly larger than that obtained with the 21G needle. Further multicenter randomized studies are needed to identify the utility of the Flex 19G needle in diagnosing/subtyping lymphoproliferative disorders and adequacy for molecular testing in non-small cell lung cancer.
AB - Background:Previous studies have shown that needle gauge size has no significant impact on diagnostic yield during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Our objective was to determine whether cell blocks obtained via the new Flex 19G EBUS-TBNA needle would contain more cellular material based on cell area compared with those obtained from a 21G needle.Methods:A prospective analysis of patients undergoing EBUS-TBNA at our institutions was performed. Sampling of the same lesion(s) with both the Flex 19G and 21G needles was performed in an alternating manner. In total, 47 patients with suspected lung cancer or mediastinal/hilar lymphadenopathy were included with a total of 83 lesions biopsied. Cell block area was calculated using the Aperio ImageScope software.Results:Mean cell area in the Flex 19G group was 7.34±12.46 mm2 compared with 5.23±10.73 mm2 in the 21G group (P=0.02). In the malignant subgroup, the average cell area was 16.16±16.30 mm2 in the Flex 19G group versus 11.09±15.55 mm2 in the 21G group (P=0.02). No significant difference was noted in the mean cell area within the nonmalignant subgroup, 1.80±3.01 mm2 in the 19G group versus 1.56±1.79 mm2 in the 21G group (P=0.60).Conclusion:The cell area obtained via the 19G needle was significantly larger than that obtained with the 21G needle. Further multicenter randomized studies are needed to identify the utility of the Flex 19G needle in diagnosing/subtyping lymphoproliferative disorders and adequacy for molecular testing in non-small cell lung cancer.
KW - 19G EBUS needle
KW - diagnostic bronchoscopy
KW - endobronchial ultrasound
KW - lymphadenopathy
KW - transbronchial needle aspiration
UR - http://www.scopus.com/inward/record.url?scp=85058858434&partnerID=8YFLogxK
U2 - 10.1097/LBR.0000000000000562
DO - 10.1097/LBR.0000000000000562
M3 - Article
AN - SCOPUS:85058858434
SN - 1944-6586
VL - 26
SP - 237
EP - 244
JO - Journal of Bronchology and Interventional Pulmonology
JF - Journal of Bronchology and Interventional Pulmonology
IS - 4
ER -
