Tissue and erythrocyte distribution of digoxin in infants

Rafael Gorodischer, William J. Jusko, Sumner J. Yaffe

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Abstract

The distribution of digoxin in the myocardium, skeletal muscle, erythrocytes, and plasma (or serum) was studied in 19 infants. There was a linear relationship between myocardium and serum concentrations and no saturation was observed over the serum concentration range of 0.5-8.6 ng/ml. Myocardium uptake of digoxin was nearly twice as great in infants as in adults at any given serum concentration. Erythrocyte: plasma concentration ratios of digoxin were one-third smaller during digitalization than during maintenance digoxin therapy. The latter ratios were also three times greater in infants than found previously in adults. Their findings are consistent with a greater apparent volume of distribution of digoxin in infants and may partly explain the unusually large therapeutic doses needed in infants.

Original languageEnglish
Pages (from-to)256-263
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume19
Issue number3
DOIs
StatePublished - 1 Jan 1976
Externally publishedYes

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