TMS in bipolar disorder

Nimrod Grisaru; Bella Chudakov; Alex Kaptsan; Alona Shaldubina; Julia Applebaum; R. H. Belmaker

doi:10.1093/oxfordhb/9780198568926.013.0041

TMS in bipolar disorder

Nimrod Grisaru, Bella Chudakov, Alex Kaptsan, Alona Shaldubina, Julia Applebaum, R. H. Belmaker

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This article reviews the existing animal and human literature on the clinical potential of transcranial magnetic stimulation (TMS) in mania and bipolar depression, and discusses potential future directions for this work. Studies of TMS in depression and normal volunteers suggested lateral specificity of TMS-induced mood effects. Clinical trials to compare left versus right prefrontal TMS in mania have been developed. Studies to understand the effect of TMS in bipolar depression have been undertaken. The results show efficacy similar to that for unipolar depression. But this does not provide support for the concept of TMS as an anti-bipolar, or mood-stabilizing, treatment. The utility of TMS as prophylaxis for subsequent manic or depressive episodes has not been reported in bipolar disorder. More work is needed to clarify the risk of mood switch, and the potential of TMS as prophylaxis against future manic or depressive episodes.

Original language	English
Title of host publication	Oxford Handbook of Transcranial Stimulation
Publisher	Oxford University Press
ISBN (Electronic)	9780191744013
ISBN (Print)	9780198568926
DOIs	https://doi.org/10.1093/oxfordhb/9780198568926.013.0041
State	Published - 21 Nov 2012
Externally published	Yes

Keywords

Bipolar depression
Clinical trials
Lateral specificity
Mania
Mood-stabilizing treatment

ASJC Scopus subject areas

General Psychology

Access to Document

10.1093/oxfordhb/9780198568926.013.0041

Cite this

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AU - Kaptsan, Alex

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AU - Applebaum, Julia

AU - Belmaker, R. H.

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TMS in bipolar disorder

Abstract

Keywords

ASJC Scopus subject areas

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