TNF and PGE2 in human monocyte-derived macrophages infected with Chlamydia trachomatis

E. Manor, I. Sarov, E. Schmitz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this study levels of prostaglandin E2 (PGE2), tumour necrosis factor (TNF) and interleukin-1 (IL-1) alpha in medium from monocyte derived macrophages (MdM) infected with Chlamydia trachomatis (L2/434/Bu or K biovars). TNF and PGE2 were found in both cases while IL-1 alpha was not detected. Both TNF and PGE2 levels were higher in the medium of the MdM infected with K biovars. TNF reached maximum levels 24 h postinfection, and then declined, while PGE2 levels increased continuously during the infection time up to 96 h post-infection. Addition of dexamethasone inhibited production of TNF and PGE2. Inhibition of PGE2 production by indomethacin resulted in increased production of TNF, while addition of PGE2 caused partial inhibition of TNF production from infected MdM.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalMediators of Inflammation
Volume2
Issue number5
DOIs
StatePublished - 1 Jan 1993

Keywords

  • Chlamydia trachomatis
  • Monocyte derived macrophages
  • Prostaglandin E
  • Tumour necrosis factor

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