To Fis or not to Fuse? This is the question!

Marc Liesa, Alexander Van der Bliek, Orian S. Shirihai

Research output: Contribution to journalComment/debate

10 Scopus citations


Mitochondrial shaping proteins are categorized as fusion and fission factors based on their opposing actions on the architecture of mitochondria. Mammalian Fis1 fragments mitochondria into small units and was initially considered a major mitochondrial fission factor, with this major role being challenged. Yu et al () define that Fis1 induces mitochondrial fragmentation by blocking mitochondrial fusion. This study highlights the limitation of categorizing mitochondrial dynamics proteins based on architecture measurements, given the general tendency to associate fragmentation with activation of fission.

Original languageEnglish
Article numbere101839
JournalEMBO Journal
Issue number8
StatePublished - 15 Apr 2019
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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