Tolerance Induction to H‐2 Central Region Target Antigens: In Vivo/in Vitro Correlations

O. J. KUPERMAN, H. W. SOLLINGER, F. H. BACH

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Tolerance was induced against cytotoxic target determinants coded for by genes of the I region. Neonatal recipients were immunized with high doses of cells from an I region incompatible donor. Nonreactivity in adult life did not reflect extensive donor cell chimerism, since the great majority of cells in spleens of animals rendered tolerant were of host phenotype. Although specific nonresponsiveness in CML could be induced by these protocols, the MLC proliferative response was in most cases still present although very much decreased. In only a very occasional animal was complete nonreactivity in MLC seen. The nonresponse in CML was paralleled by acceptance of thyroid allografts as measured by radioactive iodine incorporation and morphological studies.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalScandinavian Journal of Immunology
Volume6
Issue number5
DOIs
StatePublished - 1 Jan 1977
Externally publishedYes

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