Tolerance to effects of clonidine and morphine on sulfobromophthalein in disposition in mice

Z. Ben-Zvi, C. E. Graham, A. Hurwitz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Chronic treatment of mice with clonidine or morphine caused tolerance to the analgesic and thermoregulatory effects of these drugs. After chronic morphine, mice also became tolerant to the analgesic and thermoregulatory effects of clonidine. Cross tolerance to the hypothermic effect of morphine was demonstrated after chronic clonidine administration, but no diminution of morphine-induced analgesia could be shown. Morphine and clonidine acutely increased the retention of sulfobromophthalein (BSP) in plasma and liver. Chronic dosing with morphine or clonidine caused partial tolerance and cross-tolerance to the rise in hepatic BSP caused by an acute challenge with either agonist. However, both drugs elevated plasma BSP levels similarly in tolerant and non-tolerant mice. Thus, regimens which readily induced tolerance to the analgesic and hypothermic effects of morphine or clonidine were only partially effective in modifying the acute hepatobiliary effects of these drugs.

Original languageEnglish
Pages (from-to)1617-1623
Number of pages7
JournalLife Sciences
Volume40
Issue number16
DOIs
StatePublished - 20 Apr 1987

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Pharmacology, Toxicology and Pharmaceutics

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