Abstract
Introduction: Short-term exposure to fine particles (PM2.5) is associated with reduced heart rate variability (HRV), a strong predictor of cardiac mortality among the elderly. Identifying modifiable factors that confer susceptibility is essential for personalized intervention. We evaluated whether Toll-Like Receptor 2 (TLR2) methylation [[Unable to Display Character: –]] a reversible epigenetic process affecting immunoregulation [[Unable to Display Character: –]] modified the effect of PM2.5 on HRV, and investigated the impact of flavonoid and folic acid intake on TLR2 methylation.
Original language | English |
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Article number | Abstract 15898 |
Number of pages | 1 |
Journal | Circulation |
Volume | 130 |
Issue number | suppl.2 |
State | Published - 25 Nov 2014 |
Keywords
- Heart rate/Heart rate variability
- Epidemiology
- Diet
- Inflammation
- Gene expression