Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study

Jia Zhong, Elena Colicino, Xinyi Lin, Amar Mehta, Itai Kloog, Antonella Zanobetti, Hyang-Min Byun, Marie -Abele Bind, Laura Cantone, Diddier Prada, Letizia Tarantini, David Sparrow, Pantel Vokonas, Joel Schwartz, Andrea Baccarelli

Research output: Contribution to journalMeeting Abstract

Abstract

Introduction: Short-term exposure to fine particles (PM2.5) is associated with reduced heart rate variability (HRV), a strong predictor of cardiac mortality among the elderly. Identifying modifiable factors that confer susceptibility is essential for personalized intervention. We evaluated whether Toll-Like Receptor 2 (TLR2) methylation [[Unable to Display Character: –]] a reversible epigenetic process affecting immunoregulation [[Unable to Display Character: –]] modified the effect of PM2.5 on HRV, and investigated the impact of flavonoid and folic acid intake on TLR2 methylation.
Original languageEnglish
Article numberAbstract 15898
Number of pages1
JournalCirculation
Volume130
Issue numbersuppl.2
StatePublished - 25 Nov 2014

Keywords

  • Heart rate/Heart rate variability
  • Epidemiology
  • Diet
  • Inflammation
  • Gene expression

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