Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study

Jia Zhong; Elena Colicino; Xinyi Lin; Amar Mehta; Itai Kloog; Antonella Zanobetti; Hyang-Min Byun; Marie -Abele Bind; Laura Cantone; Diddier Prada; Letizia Tarantini; David Sparrow; Pantel Vokonas; Joel Schwartz; Andrea Baccarelli

Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study

Jia Zhong, Elena Colicino, Xinyi Lin, Amar Mehta, Itai Kloog, Antonella Zanobetti, Hyang-Min Byun, Marie -Abele Bind, Laura Cantone, Diddier Prada, Letizia Tarantini, David Sparrow, Pantel Vokonas, Joel Schwartz, Andrea Baccarelli

Department of Environmental, Geoinformatics and Urban Planning Sciences

Research output: Contribution to journal › Meeting Abstract

Abstract

Introduction: Short-term exposure to fine particles (PM2.5) is associated with reduced heart rate variability (HRV), a strong predictor of cardiac mortality among the elderly. Identifying modifiable factors that confer susceptibility is essential for personalized intervention. We evaluated whether Toll-Like Receptor 2 (TLR2) methylation [[Unable to Display Character: –]] a reversible epigenetic process affecting immunoregulation [[Unable to Display Character: –]] modified the effect of PM2.5 on HRV, and investigated the impact of flavonoid and folic acid intake on TLR2 methylation.

Original language	English
Article number	Abstract 15898
Number of pages	1
Journal	Circulation
Volume	130
Issue number	suppl.2
State	Published - 25 Nov 2014

Keywords

Heart rate/Heart rate variability
Epidemiology
Diet
Inflammation
Gene expression

Cite this

Zhong, J., Colicino, E., Lin, X., Mehta, A., Kloog, I., Zanobetti, A., Byun, H.-M., Bind, M. .-A., Cantone, L., Prada, D., Tarantini, L., Sparrow, D., Vokonas, P., Schwartz, J., & Baccarelli, A. (2014). Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study. Circulation, 130(suppl.2), Article Abstract 15898.

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title = "Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study",

abstract = "Introduction: Short-term exposure to fine particles (PM2.5) is associated with reduced heart rate variability (HRV), a strong predictor of cardiac mortality among the elderly. Identifying modifiable factors that confer susceptibility is essential for personalized intervention. We evaluated whether Toll-Like Receptor 2 (TLR2) methylation [[Unable to Display Character: –]] a reversible epigenetic process affecting immunoregulation [[Unable to Display Character: –]] modified the effect of PM2.5 on HRV, and investigated the impact of flavonoid and folic acid intake on TLR2 methylation.",

keywords = "Heart rate/Heart rate variability, Epidemiology, Diet, Inflammation, Gene expression",

author = "Jia Zhong and Elena Colicino and Xinyi Lin and Amar Mehta and Itai Kloog and Antonella Zanobetti and Hyang-Min Byun and Bind, \{Marie -Abele\} and Laura Cantone and Diddier Prada and Letizia Tarantini and David Sparrow and Pantel Vokonas and Joel Schwartz and Andrea Baccarelli",

year = "2014",

month = nov,

day = "25",

language = "English",

volume = "130",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "suppl.2",

}

Zhong, J, Colicino, E, Lin, X, Mehta, A, Kloog, I, Zanobetti, A, Byun, H-M, Bind, M-A, Cantone, L, Prada, D, Tarantini, L, Sparrow, D, Vokonas, P, Schwartz, J & Baccarelli, A 2014, 'Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study', Circulation, vol. 130, no. suppl.2, Abstract 15898.

TY - JOUR

T1 - Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction

T2 - The Normative Aging Study

AU - Zhong, Jia

AU - Colicino, Elena

AU - Lin, Xinyi

AU - Mehta, Amar

AU - Kloog, Itai

AU - Zanobetti, Antonella

AU - Byun, Hyang-Min

AU - Bind, Marie -Abele

AU - Cantone, Laura

AU - Prada, Diddier

AU - Tarantini, Letizia

AU - Sparrow, David

AU - Vokonas, Pantel

AU - Schwartz, Joel

AU - Baccarelli, Andrea

PY - 2014/11/25

Y1 - 2014/11/25

N2 - Introduction: Short-term exposure to fine particles (PM2.5) is associated with reduced heart rate variability (HRV), a strong predictor of cardiac mortality among the elderly. Identifying modifiable factors that confer susceptibility is essential for personalized intervention. We evaluated whether Toll-Like Receptor 2 (TLR2) methylation [[Unable to Display Character: –]] a reversible epigenetic process affecting immunoregulation [[Unable to Display Character: –]] modified the effect of PM2.5 on HRV, and investigated the impact of flavonoid and folic acid intake on TLR2 methylation.

AB - Introduction: Short-term exposure to fine particles (PM2.5) is associated with reduced heart rate variability (HRV), a strong predictor of cardiac mortality among the elderly. Identifying modifiable factors that confer susceptibility is essential for personalized intervention. We evaluated whether Toll-Like Receptor 2 (TLR2) methylation [[Unable to Display Character: –]] a reversible epigenetic process affecting immunoregulation [[Unable to Display Character: –]] modified the effect of PM2.5 on HRV, and investigated the impact of flavonoid and folic acid intake on TLR2 methylation.

KW - Heart rate/Heart rate variability

KW - Epidemiology

KW - Diet

KW - Inflammation

KW - Gene expression

M3 - Meeting Abstract

SN - 0009-7322

VL - 130

JO - Circulation

JF - Circulation

IS - suppl.2

M1 - Abstract 15898

ER -

Toll-Like Receptor 2 Methylation and Dietary Flavonoid Intake Modify the Association Between Fine Particle Exposure and Cardiac Autonomic Dysfunction: The Normative Aging Study

Abstract

Keywords

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