TY - JOUR
T1 - Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major
T2 - A double-blind control study
AU - El-On, Joseph
AU - Halevy, Sima
AU - Grunwald, Marcello H.
AU - Weinrauch, Louis
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Background: A controlled study of the efficacy of topical paromomycin sulfate (PR) and methylbenzethonium chloride (MBCI) in cutaneous leishmaniasis (CL) has not yet been performed. Objective: The therapeutic effect of an ointment containing 15% PR and either 12% or 5% MBCI (15/12 or 15/5 P-ointment) on patients suffering from Old World CL was examined in a randomized, double-blind, cross-over study. Methods: Thirty-nine patients with Old World CL caused by Leishmania major were treated topically, twice daily, for 10 to 20 days with 15/12 or 15/5 P-ointment and 10 to 20 days with a placebo ointment to achieve a total of 30 days of treatment in all groups. Results: In the P-ointment-treated groups, 74.2% (29 of 39 patients) of the patients were cured versus 26.6% (4 of 15 patients) in the placebo-treated group. Little difference was found between the 15/12 and 15/5 P-ointment groups. Conclusion: In most of the patients treated with the active ingredients, total elimination of the parasites was achieved within the first 10 days of treatment.
AB - Background: A controlled study of the efficacy of topical paromomycin sulfate (PR) and methylbenzethonium chloride (MBCI) in cutaneous leishmaniasis (CL) has not yet been performed. Objective: The therapeutic effect of an ointment containing 15% PR and either 12% or 5% MBCI (15/12 or 15/5 P-ointment) on patients suffering from Old World CL was examined in a randomized, double-blind, cross-over study. Methods: Thirty-nine patients with Old World CL caused by Leishmania major were treated topically, twice daily, for 10 to 20 days with 15/12 or 15/5 P-ointment and 10 to 20 days with a placebo ointment to achieve a total of 30 days of treatment in all groups. Results: In the P-ointment-treated groups, 74.2% (29 of 39 patients) of the patients were cured versus 26.6% (4 of 15 patients) in the placebo-treated group. Little difference was found between the 15/12 and 15/5 P-ointment groups. Conclusion: In most of the patients treated with the active ingredients, total elimination of the parasites was achieved within the first 10 days of treatment.
UR - http://www.scopus.com/inward/record.url?scp=0026689982&partnerID=8YFLogxK
U2 - 10.1016/0190-9622(92)70175-F
DO - 10.1016/0190-9622(92)70175-F
M3 - Article
AN - SCOPUS:0026689982
SN - 0190-9622
VL - 27
SP - 227
EP - 231
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -