Abstract
A new record: The largest chemically synthesized polypeptide composed of 304 residues, which corresponds to folded K48-tetraubiquitin, has been achieved (see scheme). The presented synthetic method could be applied to any of the remaining tetraubiquitin chains, and should ultimately assist ongoing efforts to unravel how the remarkable diversity of ubiquitin signaling is achieved.
Original language | English |
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Pages (from-to) | 6137-6141 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 27 |
DOIs | |
State | Published - 27 Jun 2011 |
Keywords
- amino acids
- ligation
- peptides
- proteins
- ubiquitin chains
ASJC Scopus subject areas
- Catalysis
- General Chemistry