Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein

K. S.Ajish Kumar, Sudhir N. Bavikar, Liat Spasser, Tal Moyal, Shimrit Ohayon, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

189 Scopus citations

Abstract

A new record: The largest chemically synthesized polypeptide composed of 304 residues, which corresponds to folded K48-tetraubiquitin, has been achieved (see scheme). The presented synthetic method could be applied to any of the remaining tetraubiquitin chains, and should ultimately assist ongoing efforts to unravel how the remarkable diversity of ubiquitin signaling is achieved.

Original languageEnglish
Pages (from-to)6137-6141
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number27
DOIs
StatePublished - 27 Jun 2011

Keywords

  • amino acids
  • ligation
  • peptides
  • proteins
  • ubiquitin chains

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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