Total chemical synthesis of di-ubiquitin chains

K. S.Ajish Kumar; Liat Spasser; Lesly A. Erlich; Sudhir N. Bavikar; Ashraf Brik

doi:10.1002/anie.201003763

Total chemical synthesis of di-ubiquitin chains

K. S.Ajish Kumar, Liat Spasser, Lesly A. Erlich, Sudhir N. Bavikar, Ashraf Brik

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Building the chains: A general and effective approach for the total chemical synthesis of all the di-ubiquitin chains (see picture) is presented. The behavior of the synthetic chains in the presence of isopeptidase T, an enzyme responsible for the disassembly of the majority of unanchored polyubiquitin in vivo, was examined.

Original language	English
Pages (from-to)	9126-9131
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	48
DOIs	https://doi.org/10.1002/anie.201003763
State	Published - 22 Nov 2010

Keywords

ligation
peptides
proteins
synthetic methods
ubiquitin

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201003763

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abstract = "Building the chains: A general and effective approach for the total chemical synthesis of all the di-ubiquitin chains (see picture) is presented. The behavior of the synthetic chains in the presence of isopeptidase T, an enzyme responsible for the disassembly of the majority of unanchored polyubiquitin in vivo, was examined.",

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AU - Kumar, K. S.Ajish

AU - Spasser, Liat

AU - Erlich, Lesly A.

AU - Bavikar, Sudhir N.

AU - Brik, Ashraf

PY - 2010/11/22

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AB - Building the chains: A general and effective approach for the total chemical synthesis of all the di-ubiquitin chains (see picture) is presented. The behavior of the synthetic chains in the presence of isopeptidase T, an enzyme responsible for the disassembly of the majority of unanchored polyubiquitin in vivo, was examined.

KW - ligation

KW - peptides

KW - proteins

KW - synthetic methods

KW - ubiquitin

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ER -

Total chemical synthesis of di-ubiquitin chains

Abstract

Keywords

ASJC Scopus subject areas

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