Total chemical synthesis of di-ubiquitin chains

K. S.Ajish Kumar, Liat Spasser, Lesly A. Erlich, Sudhir N. Bavikar, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Building the chains: A general and effective approach for the total chemical synthesis of all the di-ubiquitin chains (see picture) is presented. The behavior of the synthetic chains in the presence of isopeptidase T, an enzyme responsible for the disassembly of the majority of unanchored polyubiquitin in vivo, was examined.

Original languageEnglish
Pages (from-to)9126-9131
Number of pages6
JournalAngewandte Chemie - International Edition
Volume49
Issue number48
DOIs
StatePublished - 22 Nov 2010

Keywords

  • ligation
  • peptides
  • proteins
  • synthetic methods
  • ubiquitin

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (all)

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