Total chemical synthesis of di-ubiquitin chains

K. S.Ajish Kumar, Liat Spasser, Lesly A. Erlich, Sudhir N. Bavikar, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

147 Scopus citations


Building the chains: A general and effective approach for the total chemical synthesis of all the di-ubiquitin chains (see picture) is presented. The behavior of the synthetic chains in the presence of isopeptidase T, an enzyme responsible for the disassembly of the majority of unanchored polyubiquitin in vivo, was examined.

Original languageEnglish
Pages (from-to)9126-9131
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number48
StatePublished - 22 Nov 2010


  • ligation
  • peptides
  • proteins
  • synthetic methods
  • ubiquitin

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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