Total lymphoid irradiation, anti-lymphocyte globulin and Campath 1-G for immunosuppression prior to bone marrow transplantation for aplastic anomia after repeated graft rejection

R. Or, J. Mehta, J. Kapelushnik, M. Aker, E. Naparstek, A. Nagler, G. Cividalli, S. Slavin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Allogeneic BMT for severe aplastic anemia is associated with a significant rate of graft rejection, especially in patients who have been previously transfused. We report a child with aplastic anemia who rejected donor marrow twice despite adequate immunosuppression as part of the conditioning therapy but engrafted successfully following combined administration of three modalities of immunosuppression: antithymocyte globulin, total lymphoid irradiation and the monoclonal antibody Cannpath-1G. Restriction fragment length polymorphism studies > 1 year after BMT show full donor hematopoiesis with no evidence of autologous recovery.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalBone Marrow Transplantation
Volume13
Issue number1
StatePublished - 23 Feb 1994
Externally publishedYes

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