Total syntheses of cannabidiol and Δ1-tetrahydrocannabinol metabolites

Naftali Lander, Zvi Ben-Zvi, Raphael Mechoulam, Bill Martin, Marrianne Nordqvist, Stig Agurell

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


10-Hydroxycannabidiol [2-(10-hydroxy-p-mentha-1,8-dien-3-yl)-5- pentylresorcinol] (Va), which has tentatively been identified as a cannabidiol metabolite, as well as 6α- and 6β-hydroxy-cannabidiol [(VIa) and (VIIa)], which are now reported to be metabolites, have been prepared from cannabidiol. Total syntheses of 7-hydroxycannabidiol triacetate (IIIb) and 7-acetoxy-Δ1-tetrahydrocannabinol (9-acetoxymethyl-6a,7,8,10a- tetrahydro-6,6-dimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol) (IIc) from p-mentha-1,8-dien-7-ol are described.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number1
StatePublished - 1 Jan 1976
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


Dive into the research topics of 'Total syntheses of cannabidiol and Δ1-tetrahydrocannabinol metabolites'. Together they form a unique fingerprint.

Cite this