Total synthesis of pyoverdin D

Roi Mashiach, Michael M. Meijler

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including δN-formyl-δN-hydroxy-l-ornithine, and a catechol containing chiral chromophore. Here, we report the first total synthesis of pyoverdin D.

Original languageEnglish
Pages (from-to)1702-1705
Number of pages4
JournalOrganic Letters
Volume15
Issue number7
DOIs
StatePublished - 5 Apr 2013

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