Toward Polymeric Room Temperature Acid Generators

Joel W. Roberts, Amie N. Lanzendorf, Jazmin E. Aguilar-Romero, Mara L. Paterson, Catherine A. Jalomo, Ephraim G. Morado, Steven C. Zimmerman

Research output: Contribution to journalArticlepeer-review

Abstract

Although a variety of acid-generating molecules have been developed, the formation of toxic byproducts and the need for light-activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of biocompatible acid-generators. Herein, we report 4-hydroxybenzyl chloride derivatives that generate hydrochloric acid via hydrolysis at the benzylic position at room temperature in the absence of light. Utilizing the acetal protected 4-hydroxybenzyl chloride scaffold, we access a myriad of compounds that generate acid at different rates.

Original languageEnglish
JournalChemistryOpen
DOIs
StateAccepted/In press - 1 Jan 2024
Externally publishedYes

Keywords

  • Acid amplification
  • Acid generator
  • Cancer
  • Drug delivery
  • Extra cellular pH

ASJC Scopus subject areas

  • General Chemistry

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