Towards personalized mental healthcare: An electrochemically-amplified biosensor for clozapine antipsychotic treatment monitoring

H. Ben-Yoav, T. E. Winkler, S. E. Chocron, G. R. Costa, S. M. Restaino, N. Woolsey, E. Kim, D. L. Kelly, G. P. Payne, R. Ghodssi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We present the first demonstration of a micro-scale electrochemically- amplifying biosensor for real-time monitoring of the antipsychotic clozapine. The amplification probe consists of a catechol-modified chitosan redox-cycling system, which increases the electrochemical signal generated by clozapine. Modified microelectrodes show a 2.5-fold higher clozapine oxidative current density compared to bare microelectrodes. Chitosan electrodeposition at the milli- and micro-scale yields deposition rates of 5.0±0.8 nm/s and 3.0±0.6 nm/s, respectively. Catechol grafting duration demonstrates positive correlation with the signal amplification, modeled using the oxidizing mediator ferrocenedimethanol. Moreover, the feasibility of the biosensor to distinguish 5, 25, and 50 μM of clozapine is successfully shown.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1167-1169
Number of pages3
ISBN (Print)9781632666246
StatePublished - 1 Jan 2013
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 27 Oct 201331 Oct 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume2

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/TerritoryGermany
CityFreiburg
Period27/10/1331/10/13

Keywords

  • Antipsychotic clozapine
  • Biosensor
  • Electrochemical amplifier
  • Mental health
  • Redox-cycling

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