TY - JOUR
T1 - Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility
T2 - A scientometric analysis
AU - Baskaran, Saradha
AU - Agarwal, Ashok
AU - Panner Selvam, Manesh Kumar
AU - Finelli, Renata
AU - Robert, Kathy Amy
AU - Iovine, Concetta
AU - Pushparaj, Peter Natesan
AU - Samanta, Luna
AU - Harlev, Avi
AU - Henkel, Ralf
N1 - Publisher Copyright:
© 2019 The Author(s).
PY - 2019/12/26
Y1 - 2019/12/26
N2 - Background: This article describes the research trends in sperm DNA fragmentation (SDF) over the past 20 years (1999-2018) using a scientometric approach. Methods: A stepwise approach was adopted to retrieve scientometric data (articles per year, authors, affiliations, journals, countries) from Scopus and analyze the publication pattern of SDF with reference to key areas of research in the field of Andrology. Results: A total of 2121 articles were retrieved related to SDF. Our data revealed an increasing research trend in SDF (n = 33 to n = 173) over the past 20 years (R2 = 0.894). Most productive country in publications was the USA (n = 450), while Agarwal A. (n = 129) being the most productive author. Most of the articles in SDF were primarily focused on lifestyle (n = 157), asthenozoospermia (n = 135) and varicocele (130). Mechanistic studies on SDF were published twice as much as prognostic/diagnostic studies, with significant emphasis on oxidative stress. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was the most widely used technique to evaluate SDF. Publications on SDF related to assisted reproductive techniques also showed a linear increasing trend (R2 = 0.933). Conclusions: Our analysis revealed an increasing trend in SDF publications predominantly investigating lifestyle, asthenozoospermia and varicocele conditions with TUNEL being the most widely used technique. A substantial increase in research is warranted to establish SDF as prognostic/diagnostic parameter to evaluate clinical scenarios and ART outcomes.
AB - Background: This article describes the research trends in sperm DNA fragmentation (SDF) over the past 20 years (1999-2018) using a scientometric approach. Methods: A stepwise approach was adopted to retrieve scientometric data (articles per year, authors, affiliations, journals, countries) from Scopus and analyze the publication pattern of SDF with reference to key areas of research in the field of Andrology. Results: A total of 2121 articles were retrieved related to SDF. Our data revealed an increasing research trend in SDF (n = 33 to n = 173) over the past 20 years (R2 = 0.894). Most productive country in publications was the USA (n = 450), while Agarwal A. (n = 129) being the most productive author. Most of the articles in SDF were primarily focused on lifestyle (n = 157), asthenozoospermia (n = 135) and varicocele (130). Mechanistic studies on SDF were published twice as much as prognostic/diagnostic studies, with significant emphasis on oxidative stress. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was the most widely used technique to evaluate SDF. Publications on SDF related to assisted reproductive techniques also showed a linear increasing trend (R2 = 0.933). Conclusions: Our analysis revealed an increasing trend in SDF publications predominantly investigating lifestyle, asthenozoospermia and varicocele conditions with TUNEL being the most widely used technique. A substantial increase in research is warranted to establish SDF as prognostic/diagnostic parameter to evaluate clinical scenarios and ART outcomes.
KW - Diagnosis
KW - DNA fragmentation
KW - Infertility, male
KW - Prognosis
KW - Publications
KW - Scientometric analysis
UR - http://www.scopus.com/inward/record.url?scp=85077260318&partnerID=8YFLogxK
U2 - 10.1186/s12958-019-0550-3
DO - 10.1186/s12958-019-0550-3
M3 - Article
C2 - 31878936
AN - SCOPUS:85077260318
SN - 1477-7827
VL - 17
JO - Reproductive Biology and Endocrinology
JF - Reproductive Biology and Endocrinology
IS - 1
M1 - 110
ER -