Transcranial magnetic stimulation in an amphetamine hyperactivity model of mania

Alona Shaldivin, Alexander Kaptsan, Robert H. Belmaker, Haim Einat, Nimrod Grisaru

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objectives: Transcranial magnetic stimulation (TMS) of the brain has been reported to have therapeutic effects in mania, as well as depression. TMS has previously been reported to have effects similar to those of electroconvulsive shock in rat models of depression. Methods: We, therefore, studied TMS in amphetamine-induced hyperactivity as a rat model of mania. Results: While two and seven daily TMS sessions significantly reduced activity after amphetamine, twice-daily TMS for 7 days enhanced activity after amphetamine. Conclusions: The results suggest that TMS treatment to rats interacts with the effects of amphetamine; the specific effects may be dependent on the schedule of treatment.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalBipolar Disorders
Volume3
Issue number1
DOIs
StatePublished - 28 Mar 2001

Keywords

  • Activity
  • Amphetamine
  • ECS
  • Mania
  • Rats
  • TMS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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