Transcranial magnetic stimulation in mania: A controlled study

Nimrod Grisaru, Bella Chudakov, Yuri Yaroslavsky, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

163 Scopus citations


Objective: Left prefrontal transcranial magnetic stimulation has been reported to have ECT-like effects in depression; therefore, the authors planned a study of transcranial magnetic stimulation in mania. Method: Sixteen patients completed a 14-day double-blind, controlled trial of right versus left prefrontal transcranial magnetic stimulation at 20 Hz (2-second duration per train, 20 trains/day for 10 treatment days). Mania was evaluated with the Mania Scale, the Brief Psychiatric Rating Scale, and the Clinical Global Impression. Results: Significantly more improvement was observed in patients treated with right than with left prefrontal transcranial magnetic stimulation. Conclusions: The therapeutic effect of transcranial magnetic stimulation in mania may show laterality opposite to its effect in depression.

Original languageEnglish
Pages (from-to)1608-1610
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - 1 Jan 1998


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