Transcranial magnetic stimulation of deep brain regions: Evidence for efficacy of the H-Coil

Abraham Zangen, Yiftach Roth, Bernhard Voller, Mark Hallett

Research output: Contribution to journalArticlepeer-review

348 Scopus citations


Objective: Standard coils used in research and the clinic for noninvasive magnetic stimulation of the human brain are not capable of stimulating deep brain regions directly. As the fields induced by these coils decrease rapidly as a function of depth, only very high intensities would allow functional stimulation of deep brain regions and such intensities would lead to undesirable side effects. We have designed a coil based on numerical simulations and phantom brain measurements that allows stimulation of deeper brain regions, termed the Hesed coil (H-coil). In the present study we tested the efficacy and some safety aspects of the H-coil on healthy volunteers. Methods: The H-coil was compared to a regular figure-8 coil in 6 healthy volunteers by measuring thresholds for activation of the abductor pollicis brevis (APB) representation in the motor cortex as a function of distance from each of the coils. Results: The rate of decrease in the coil intensity as a function of distance is markedly slower for the H-coil. The motor cortex could be activated by the H-coil at a distance of 5.5 cm compared to 2 cm with the figure-8 coil. Conclusions: The present study indicate that the H-coil is likely to have the ability of deep brain stimulation and without the need of increasing the intensity to extreme levels that would cause a much greater stimulation in cortical regions. Significance: The ability of non-invasive deep brain stimulation potentially opens a wide range of both research and therapeutic applications.

Original languageEnglish
Pages (from-to)775-779
Number of pages5
JournalClinical Neurophysiology
Issue number4
StatePublished - 1 Jan 2005
Externally publishedYes


  • Deep brain stimulation
  • Electric field
  • Magnetic coil
  • Motor threshold
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


Dive into the research topics of 'Transcranial magnetic stimulation of deep brain regions: Evidence for efficacy of the H-Coil'. Together they form a unique fingerprint.

Cite this