Transcriptional dysregulation of adipose tissue autophagy in obesity

Nitzan Maixner, Sapir Bechor, Zlata Vershinin, Tal Pecht, Nir Goldstein, Yulia Haim, Assaf Rudich

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.

Original languageEnglish
Pages (from-to)270-282
Number of pages13
JournalPhysiology
Volume31
Issue number4
DOIs
StatePublished - 1 Jul 2016

ASJC Scopus subject areas

  • Physiology

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