Transcriptional dysregulation of adipose tissue autophagy in obesity

Nitzan Maixner; Sapir Bechor; Zlata Vershinin; Tal Pecht; Nir Goldstein; Yulia Haim; Assaf Rudich

doi:10.1152/physiol.00048.2015

Transcriptional dysregulation of adipose tissue autophagy in obesity

Nitzan Maixner, Sapir Bechor, Zlata Vershinin, Tal Pecht, Nir Goldstein, Yulia Haim, Assaf Rudich

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.

Original language	English
Pages (from-to)	270-282
Number of pages	13
Journal	Physiology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1152/physiol.00048.2015
State	Published - 1 Jul 2016

ASJC Scopus subject areas

Physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/physiol.00048.2015

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abstract = "There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.",

author = "Nitzan Maixner and Sapir Bechor and Zlata Vershinin and Tal Pecht and Nir Goldstein and Yulia Haim and Assaf Rudich",

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AU - Maixner, Nitzan

AU - Bechor, Sapir

AU - Vershinin, Zlata

AU - Pecht, Tal

AU - Goldstein, Nir

AU - Haim, Yulia

AU - Rudich, Assaf

PY - 2016/7/1

Y1 - 2016/7/1

N2 - There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.

AB - There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.

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Transcriptional dysregulation of adipose tissue autophagy in obesity

Abstract

ASJC Scopus subject areas

UN SDGs

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